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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAtHU0J_ULtG30BeC-TUs8p52IPZFKy6RVcTnaUJAbI_U#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAtHU0J_ULtG30BeC-TUs8p52IPZFKy6RVcTnaUJAbI_U#_4 http://purl.org/dc/elements/1.1/identifier Chemical Society Reviews 1998 volume 27 http://www.tkuhn.ch/bel2nanopub/RAtHU0J_ULtG30BeC-TUs8p52IPZFKy6RVcTnaUJAbI_U#_4 http://purl.org/dc/elements/1.1/title Chemical Society Reviews 1998 volume 27 http://www.tkuhn.ch/bel2nanopub/RAtHU0J_ULtG30BeC-TUs8p52IPZFKy6RVcTnaUJAbI_U#_4 http://purl.org/dc/elements/1.1/type Other http://www.tkuhn.ch/bel2nanopub/RAtHU0J_ULtG30BeC-TUs8p52IPZFKy6RVcTnaUJAbI_U#_5 http://www.w3.org/ns/prov#value A pure oestrogen receptor antagonist, ICI182780 11, was subsequently discovered and is now in late-stage clinical trial. 4.3 LHRH agonists Luteinizing hormone releasing hormone (LHRH) agonists form a third class of hormonal therapy for breast cancer, albeit only in pre-menopausal women. This limitation arises from their inhibitory effect on luteinizing hormone (LH) release from the pituitary (see Fig. 4) and consequent suppression of ovarian stimulation for oestrogen production. Whilst there are LHRH antagonists in clinical study, the ability of the agonists to mimic successfully the natural inhibitory feedback effect of oestrogen at the pituitary by inducing LHRH receptor downregulation provides a rare superiority over direct blockade. 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