[ {
  "@graph" : [ {
    "@id" : "http://purl.org/np/RAuAeKyOAoSnvLp6P9KCCOv-MDIGCvPOtATe5ibl7lprg",
    "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ],
    "http://www.nanopub.org/nschema#hasAssertion" : [ {
      "@id" : "http://purl.org/np/RAuAeKyOAoSnvLp6P9KCCOv-MDIGCvPOtATe5ibl7lprg#assertion"
    } ],
    "http://www.nanopub.org/nschema#hasProvenance" : [ {
      "@id" : "http://purl.org/np/RAuAeKyOAoSnvLp6P9KCCOv-MDIGCvPOtATe5ibl7lprg#provenance"
    } ],
    "http://www.nanopub.org/nschema#hasPublicationInfo" : [ {
      "@id" : "http://purl.org/np/RAuAeKyOAoSnvLp6P9KCCOv-MDIGCvPOtATe5ibl7lprg#pubInfo"
    } ]
  } ],
  "@id" : "http://purl.org/np/RAuAeKyOAoSnvLp6P9KCCOv-MDIGCvPOtATe5ibl7lprg#Head"
}, {
  "@graph" : [ {
    "@id" : "http://identifiers.org/drugbank/DB00285",
    "@type" : [ "https://w3id.org/biolink/vocab/Drug" ],
    "http://www.w3.org/2000/01/rdf-schema#label" : [ {
      "@value" : "Venlafaxine"
    } ],
    "https://w3id.org/biolink/vocab/category" : [ {
      "@id" : "https://w3id.org/biolink/vocab/Drug"
    } ]
  }, {
    "@id" : "http://purl.obolibrary.org/obo/MONDO_0005277",
    "@type" : [ "https://w3id.org/biolink/vocab/Disease" ],
    "http://www.w3.org/2000/01/rdf-schema#label" : [ {
      "@value" : "Migraine (disorder)"
    } ],
    "https://w3id.org/biolink/vocab/category" : [ {
      "@id" : "https://w3id.org/biolink/vocab/Disease"
    } ]
  }, {
    "@id" : "http://purl.org/np/RAuAeKyOAoSnvLp6P9KCCOv-MDIGCvPOtATe5ibl7lprg#association",
    "@type" : [ "https://w3id.org/biolink/vocab/ChemicalToDiseaseOrPhenotypicFeatureAssociation" ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ {
      "@id" : "http://purl.obolibrary.org/obo/MONDO_0005277"
    } ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ {
      "@id" : "https://w3id.org/biolink/vocab/treats"
    } ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ {
      "@id" : "http://identifiers.org/drugbank/DB00285"
    } ],
    "http://www.w3.org/2000/01/rdf-schema#label" : [ {
      "@value" : "Although antidepressants are not the first-line prophylactic strategy for patients with migraine, several clinical trials have proven their effectiveness in the treatment of migraine and related headache disorders (Koch and Jurgens, 2009). Especially TCAs: amitriptyline (Couch and Hassanein, 1979; Jackson et al., 2010; Kalita et al., 2013) and nortriptyline (Holroyd et al., 2001; Jackson et al., 2010) have the best evidence for use in migraine prevention. When amitriptyline is not tolerated by patients, treatment is continued with nortriptyline (Burch, 2019)."
    } ],
    "https://w3id.org/biolink/vocab/aggregator_knowledge_source" : [ {
      "@id" : "https://w3id.org/biolink/infores/knowledge-collaboratory"
    } ],
    "https://w3id.org/biolink/vocab/category" : [ {
      "@id" : "https://w3id.org/biolink/vocab/ChemicalToDiseaseOrPhenotypicFeatureAssociation"
    } ],
    "https://w3id.org/biolink/vocab/has_population_context" : [ {
      "@id" : "http://purl.org/np/RAuAeKyOAoSnvLp6P9KCCOv-MDIGCvPOtATe5ibl7lprg#context"
    } ],
    "https://w3id.org/biolink/vocab/publications" : [ {
      "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/31622593"
    } ],
    "https://w3id.org/biolink/vocab/relation" : [ {
      "@id" : "http://purl.obolibrary.org/obo/NCIT_C94303"
    } ]
  }, {
    "@id" : "http://purl.org/np/RAuAeKyOAoSnvLp6P9KCCOv-MDIGCvPOtATe5ibl7lprg#context",
    "@type" : [ "https://w3id.org/biolink/vocab/Cohort" ],
    "http://www.w3.org/2000/01/rdf-schema#label" : [ {
      "@value" : "Adults"
    } ],
    "https://w3id.org/biolink/vocab/category" : [ {
      "@id" : "https://w3id.org/biolink/vocab/Cohort"
    } ]
  } ],
  "@id" : "http://purl.org/np/RAuAeKyOAoSnvLp6P9KCCOv-MDIGCvPOtATe5ibl7lprg#assertion"
}, {
  "@graph" : [ {
    "@id" : "http://purl.org/np/RAuAeKyOAoSnvLp6P9KCCOv-MDIGCvPOtATe5ibl7lprg#assertion",
    "http://www.w3.org/ns/prov#wasAttributedTo" : [ {
      "@id" : "https://orcid.org/0000-0002-7641-6446"
    } ]
  } ],
  "@id" : "http://purl.org/np/RAuAeKyOAoSnvLp6P9KCCOv-MDIGCvPOtATe5ibl7lprg#provenance"
}, {
  "@graph" : [ {
    "@id" : "http://purl.org/np/RAuAeKyOAoSnvLp6P9KCCOv-MDIGCvPOtATe5ibl7lprg",
    "http://www.w3.org/ns/prov#generatedAtTime" : [ {
      "@type" : "http://www.w3.org/2001/XMLSchema#dateTime",
      "@value" : "2022-09-16T11:48:59.111160"
    } ],
    "http://www.w3.org/ns/prov#wasAttributedTo" : [ {
      "@id" : "https://orcid.org/0000-0002-1501-1082"
    } ],
    "https://w3id.org/np/o/ntemplate/wasCreatedFromTemplate" : [ {
      "@id" : "http://purl.org/np/RAhNHZw6Urw_Mccs4qy6Ws3C9CRuaHpQx8AwuApbWkqnY"
    } ]
  }, {
    "@id" : "http://purl.org/np/RAuAeKyOAoSnvLp6P9KCCOv-MDIGCvPOtATe5ibl7lprg#sig",
    "http://purl.org/nanopub/x/hasAlgorithm" : [ {
      "@value" : "RSA"
    } ],
    "http://purl.org/nanopub/x/hasPublicKey" : [ {
      "@value" : "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCR9fz0fKCdWOWC+pxhkQhEM/ppbdIYe5TLSdj+lJzSlv9mYBaPgrzVezSwwbmhlHBPDZa4/vHycU315BdmUGq+pXllp9+rWFfrb+kBJwhZjpG6BeyyXBsRFz4jmQVxl/ZYHilQTh/XalYzKkEAyTiEMPee4Kz61PaWOKH24CsnOQIDAQAB"
    } ],
    "http://purl.org/nanopub/x/hasSignature" : [ {
      "@value" : "QvTNDZu0ybkHA2OfJmw6iv4LUleiTt2ZUqZDOLRUzaSSjkfRwAHwi9x0LVdIWC2EdnoI+OL5Np4VTzCkfAeLtVxvMcgwvigU0iSOpvEjIXOOLhclx67wuRqXR89MAbjHkB3PaXQce+S1iBrIogNidN9s9O5tNlKid6Pw/5kpPZ0="
    } ],
    "http://purl.org/nanopub/x/hasSignatureTarget" : [ {
      "@id" : "http://purl.org/np/RAuAeKyOAoSnvLp6P9KCCOv-MDIGCvPOtATe5ibl7lprg"
    } ]
  }, {
    "@id" : "https://w3id.org/biolink/vocab/",
    "http://purl.org/pav/version" : [ {
      "@value" : "2.3.0"
    } ]
  } ],
  "@id" : "http://purl.org/np/RAuAeKyOAoSnvLp6P9KCCOv-MDIGCvPOtATe5ibl7lprg#pubInfo"
} ]