@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAuPatWKvZlcJBOIf4zAX9ibzD9WcX7mcw3skvevVjXn8> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAuPatWKvZlcJBOIf4zAX9ibzD9WcX7mcw3skvevVjXn8#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix mgi: <http://www.informatics.jax.org/marker/MGI:> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasPart: <http://purl.obolibrary.org/obo/BFO_0000051> .
@prefix ProteinComplex: <http://amigo.geneontology.org/amigo/term/GO:0043234> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix RNA: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix hasAnnotation: <http://semanticscience.org/resource/SIO_000255> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
  this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
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    a go:0042789 .
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    a ProteinComplex: .
  sub:_3 geneProductOf: mgi:1342774 ;
    a Protein: .
  sub:_4 geneProductOf: mgi:99458 ;
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  sub:_5 geneProductOf: mgi:1342774 ;
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  sub:_6 occursIn: mesh:D008099 , mesh:D018482 , species:10090 ;
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    rdf:predicate belv:directlyIncreases ;
    rdf:subject sub:_1 ;
    a rdf:Statement .
  sub:_7 dct:subject "TextLocation" ;
    rdf:value "Results" .
  sub:assertion rdfs:label "tscript(complex(p(MGI:Ppargc1a),p(MGI:Mef2c))) => r(MGI:Ppargc1a)" .
}
sub:provenance {
  beldoc: dce:description "Approximately 2000 hand curated statements drawn from 57 PubMeds." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved." ;
    dce:title "BEL Framework Small Corpus Document" ;
    dct:license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" ;
    pav:authoredBy sub:_9 ;
    pav:version "1.6" .
  sub:_8 prov:value """To confirm that the coactivation of MEF2C by PGC-1α observed in reporter gene assays
(Fig. 3B) was linked to direct binding of these two proteins, we tested whether
PGC-1α directly interacts with MEF2C on this MEF-binding site. Increasing amounts
of PGC-1α protein (amino acids 31–797) decreased the mobility of the complex
containing MEF2C bound to the MEF-binding site, as visualized by a supershift
in electrophoretic mobility-shift assays (Fig. 3D). As a control, PGC-1α protein
that lacks the MEF2C-interaction domain (amino acids 1–180; see ref. 7) was not
able to bind to MEF2C. Inclusion of an MEF2- specific antibody was able to supershift
further the protein–DNA complex containing MEF2C, PGC-1α, and the MEF2-binding
site (Fig. 3E). Neither a shift nor a supershift could be obtained when using
the mutated ΔMEF site. These results indicate that MEF2s bind to the PGC-1α
promoter and that PGC-1α coactivates MEF2 proteins on the PGC-1α promoter by a
direct protein–protein interaction.""" ;
    prov:wasQuotedFrom pubmed:12764228 .
  sub:_9 rdfs:comment "support@belframework.org" ;
    rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:12764228 ;
    prov:wasDerivedFrom beldoc: , sub:_8 .
}
sub:pubinfo {
  this: dct:created "2014-07-03T14:29:34.387+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}