@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAuZ4A0SjOHo1_G_0GbPK15RUoFOOpeHfZGhwttB22a_E> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAuZ4A0SjOHo1_G_0GbPK15RUoFOOpeHfZGhwttB22a_E#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/small_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix sfam: <http://resource.belframework.org/belframework/20131211/namespace/selventa-protein-families/> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix hasAnnotation: <http://semanticscience.org/resource/SIO_000255> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
  this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
  sub:_1 hasAgent: sub:_2 ;
    a go:0005525 .
  sub:_2 geneProductOf: sfam:RAS%20Family ;
    a Protein: .
  sub:_3 hasAgent: sub:_4 ;
    a go:0005525 .
  sub:_4 geneProductOf: sfam:RAC%20Family ;
    a Protein: .
  sub:_5 occursIn: species:9606 ;
    hasAnnotation: sub:_6 ;
    rdf:object sub:_3 ;
    rdf:predicate belv:increases ;
    rdf:subject sub:_1 ;
    a rdf:Statement .
  sub:_6 dct:subject "TextLocation" ;
    rdf:value "Review" .
  sub:assertion rdfs:label "gtp(p(SFAM:\"RAS Family\")) -> gtp(p(SFAM:\"RAC Family\"))" .
}
sub:provenance {
  beldoc: dce:description "Approximately 2000 hand curated statements drawn from 57 PubMeds." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved." ;
    dce:title "BEL Framework Small Corpus Document" ;
    dct:license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" ;
    pav:authoredBy sub:_8 ;
    pav:version "20131211" .
  sub:_7 prov:value """Localization of GTP-bound Ras to the inner surface of the cell membrane activates
several downstream effectors, most notably the serine/threonine kinase Raf, which
is the first signaling element in the MAPK pathway. 2,67,68 As shown in Figure
1, other downstream effectors of Ras include the PI3K cell survival pathway, the
small GTP-binding proteins Rac and Rho, and the stress-activated protein kinase
pathway (also referred to as the c-jun N-terminal kinase [JNK] pathway). 69-71
In addition, in response to cellular stress and cytokine stimulation mediated
through Ras, the dual-specificity p38MAPK kinases (MKK3 and MKK6) and the JNK kinases
(MKK4 and MKK7) phosphorylate p38MAPK and JNK, respectively. 72-76""" ;
    prov:wasQuotedFrom pubmed:16170185 .
  sub:_8 rdfs:comment "support@belframework.org" ;
    rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:16170185 ;
    prov:wasDerivedFrom beldoc: , sub:_7 .
}
sub:pubinfo {
  this: dct:created "2014-07-03T14:31:15.483+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}