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All Rights Reserved. http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Small Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/terms/license Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA-LCBpsiMrvcfKayEXCxbucB5VEN3D0kQElvr6YBMY-M#_4 http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/version 1.6 http://www.tkuhn.ch/bel2nanopub/RA-LCBpsiMrvcfKayEXCxbucB5VEN3D0kQElvr6YBMY-M#_3 http://www.w3.org/ns/prov#value Cationic amphiphilic drugs such as amiodarone, perhexiline, diethylaminoethoxyhexestrol (DEAEH) and tamoxifen can be first protonated in the intermembrane space of mitochondria, and then electrophoretically transported into the mitochondrial matrix thanks to the Δψm [3,4,40,42], as discussed in greater detail below. This transfer across the inner mitochondrial membrane dissipates Δψm (Figure 1) and increases the basal (state 4) mitochondrial respiration. This phenomenon, which is called 'OXPHOS uncoupling', can also be observed in the case of some mitochondrial poisons such as the protonophores 2,4-dinitrophenol (DNP) and carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP). http://www.tkuhn.ch/bel2nanopub/RA-LCBpsiMrvcfKayEXCxbucB5VEN3D0kQElvr6YBMY-M#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/18705745 http://www.tkuhn.ch/bel2nanopub/RA-LCBpsiMrvcfKayEXCxbucB5VEN3D0kQElvr6YBMY-M#_4 http://www.w3.org/2000/01/rdf-schema#comment support@belframework.org http://www.tkuhn.ch/bel2nanopub/RA-LCBpsiMrvcfKayEXCxbucB5VEN3D0kQElvr6YBMY-M#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA-LCBpsiMrvcfKayEXCxbucB5VEN3D0kQElvr6YBMY-M#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/18705745 http://www.tkuhn.ch/bel2nanopub/RA-LCBpsiMrvcfKayEXCxbucB5VEN3D0kQElvr6YBMY-M#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA-LCBpsiMrvcfKayEXCxbucB5VEN3D0kQElvr6YBMY-M#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA-LCBpsiMrvcfKayEXCxbucB5VEN3D0kQElvr6YBMY-M#_3 http://www.tkuhn.ch/bel2nanopub/RA-LCBpsiMrvcfKayEXCxbucB5VEN3D0kQElvr6YBMY-M#pubinfo http://www.tkuhn.ch/bel2nanopub/RA-LCBpsiMrvcfKayEXCxbucB5VEN3D0kQElvr6YBMY-M http://purl.org/dc/terms/created 2014-07-03T14:29:31.098+02:00 http://www.tkuhn.ch/bel2nanopub/RA-LCBpsiMrvcfKayEXCxbucB5VEN3D0kQElvr6YBMY-M http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA-LCBpsiMrvcfKayEXCxbucB5VEN3D0kQElvr6YBMY-M http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234