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http://purl.obolibrary.org/obo/BFO_0000066
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http://semanticscience.org/resource/SIO_000255
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TextLocation
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Review
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a(CHEBI:perhexiline) -> bp(GO:"regulation of oxidative phosphorylation uncoupler activity")
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http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel
http://purl.org/dc/elements/1.1/description
Approximately 2000 hand curated statements drawn from 57 PubMeds.
http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel
http://purl.org/dc/elements/1.1/rights
Copyright (c) 2011-2012, Selventa. All Rights Reserved.
http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel
http://purl.org/dc/elements/1.1/title
BEL Framework Small Corpus Document
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http://purl.org/dc/terms/license
Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License
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Cationic amphiphilic drugs such as amiodarone, perhexiline, diethylaminoethoxyhexestrol
(DEAEH) and tamoxifen can be first protonated in the intermembrane space
of mitochondria, and then electrophoretically transported into the mitochondrial
matrix thanks to the Δψm [3,4,40,42], as discussed in greater detail below. This
transfer across the inner mitochondrial membrane dissipates Δψm (Figure 1) and
increases the basal (state 4) mitochondrial respiration. This phenomenon, which
is called 'OXPHOS uncoupling', can also be observed in the case of some mitochondrial
poisons such as the protonophores 2,4-dinitrophenol (DNP) and carbonylcyanide
p-trifluoromethoxyphenylhydrazone (FCCP).
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http://www.ncbi.nlm.nih.gov/pubmed/18705745
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support@belframework.org
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Selventa
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2014-07-03T14:29:31.098+02:00
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