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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA-RRMqymnMcTOdMLSq9H-fPdjOgzyszhfm90D_E1D218#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA-RRMqymnMcTOdMLSq9H-fPdjOgzyszhfm90D_E1D218#_4 http://purl.org/dc/elements/1.1/identifier GeneRifs summary Mapkapk3 http://www.tkuhn.ch/bel2nanopub/RA-RRMqymnMcTOdMLSq9H-fPdjOgzyszhfm90D_E1D218#_4 http://purl.org/dc/elements/1.1/title GeneRifs summary Mapkapk3 http://www.tkuhn.ch/bel2nanopub/RA-RRMqymnMcTOdMLSq9H-fPdjOgzyszhfm90D_E1D218#_4 http://purl.org/dc/elements/1.1/type Online Resource http://www.tkuhn.ch/bel2nanopub/RA-RRMqymnMcTOdMLSq9H-fPdjOgzyszhfm90D_E1D218#_5 http://www.w3.org/ns/prov#value This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. http://www.tkuhn.ch/bel2nanopub/RA-RRMqymnMcTOdMLSq9H-fPdjOgzyszhfm90D_E1D218#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.tkuhn.ch/bel2nanopub/RA-RRMqymnMcTOdMLSq9H-fPdjOgzyszhfm90D_E1D218#_4 http://www.tkuhn.ch/bel2nanopub/RA-RRMqymnMcTOdMLSq9H-fPdjOgzyszhfm90D_E1D218#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA-RRMqymnMcTOdMLSq9H-fPdjOgzyszhfm90D_E1D218#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.tkuhn.ch/bel2nanopub/RA-RRMqymnMcTOdMLSq9H-fPdjOgzyszhfm90D_E1D218#_4 http://www.tkuhn.ch/bel2nanopub/RA-RRMqymnMcTOdMLSq9H-fPdjOgzyszhfm90D_E1D218#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA-RRMqymnMcTOdMLSq9H-fPdjOgzyszhfm90D_E1D218#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA-RRMqymnMcTOdMLSq9H-fPdjOgzyszhfm90D_E1D218#_5 http://www.tkuhn.ch/bel2nanopub/RA-RRMqymnMcTOdMLSq9H-fPdjOgzyszhfm90D_E1D218#pubinfo http://www.tkuhn.ch/bel2nanopub/RA-RRMqymnMcTOdMLSq9H-fPdjOgzyszhfm90D_E1D218 http://purl.org/dc/terms/created 2014-07-03T14:29:43.945+02:00 http://www.tkuhn.ch/bel2nanopub/RA-RRMqymnMcTOdMLSq9H-fPdjOgzyszhfm90D_E1D218 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA-RRMqymnMcTOdMLSq9H-fPdjOgzyszhfm90D_E1D218 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234