. . . . . . . . . . . . . . . . . . . . . . . "TextLocation" . "Review" . "a(CHEBIID:53490) -> surf(complex(p(HGNC:ITGAM),p(HGNC:ITGB2)))" . "Approximately 2000 hand curated statements drawn from 57 PubMeds." . "Copyright (c) 2011-2012, Selventa. All Rights Reserved." . "BEL Framework Small Corpus Document" . "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" . . "20131211" . "Preformed Mac-1 is stored in granules in neutrophils and can be rapidly mobilized\nto the neutrophil surface after exposure to degranulation stimuli such as the bacterial\npeptide fMLP or to cytokines (Altieri and Edgington, 1988). However, it\nis not yet competent for ligand binding. The ligand binding site lies on an extracellular\nregion of the α subunit called the I domain, that is inaccessible to\npotential ligands unless integrins are activated. Integrin activation involves a\nconformational change such that the I domain is exposed (Oxvig et al., 1999). This\nchange may be induced by phosphorylation of the cytoplasmic tail of the β subunit\n(Buyon et al., 1997), possibly through a pathway involving the small GTP-binding\nprotein Rho, but this is still unclear." . . "support@belframework.org" . "Selventa" . . . . "2014-07-03T14:31:18.661+02:00"^^ . . .