. . . . . . . . . . . . . . . . . "TextLocation" . "Results" . "tscript(p(MGI:Ctnnb1)) => r(MGI:Bmp4)" . "Approximately 2000 hand curated statements drawn from 57 PubMeds." . "Copyright (c) 2011-2012, Selventa. All Rights Reserved." . "BEL Framework Small Corpus Document" . "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" . . "20131211" . "Co-transfection of luciferase reporter plasmids containing these sequences along with\nexpression plasmids encoding either an activated β-catenin containing mutations\nin the GSK-3h phosphorylation sites (β-catenin/4145) or with a TCF3-VP16 fusion\nprotein demonstrated that both promoter sequences could be activated by transcriptional\nmediators of Wnt signaling (Figs. 7A and B). Addition of both h-catenin/4154\nand TCF3-VP16 resulted in cooperative activation of both promoters (Figs.\n7A and B). Furthermore, a dominantnegative TCF3 construct repressed both BMP4\nand N-myc promoters (Figs. 7C and D). Chromatin immunoprecipitation assays show\nthat β-catenin associates with the conserved LEF/TCF DNA binding sites located\nin the BMP4 and N-myc promoters, indicating direct regulation of these promoters\nby canonical Wnt signaling (Figs. 7E and F). Together, these results demonstrate\nthat BMP4 and Nmyc are targets of Wnt/β-catenin signaling in lung airway epithelium." . . "support@belframework.org" . "Selventa" . . . . "2014-07-03T14:31:16.857+02:00"^^ . . .