sub:provenance {
beldoc: dce:description "Approximately 2000 hand curated statements drawn from 57 PubMeds." ;
dce:rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved." ;
dce:title "BEL Framework Small Corpus Document" ;
dc:license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" ;
pav:authoredBy sub:_8 ;
pav:version "1.6" .
sub:_7 prov:value """The β-casein promoter, known to be induced by Stat5 when activated by prolactin via
prolactin receptors and JAK2, was next used to test the function of the phosphorylated
Stat5. T47D-YB cells were pretreated with either R5020 or ethanol vehicle
for 48 h. Cells were then washed, transfected with a β-casein promoter-luciferase
reporter, treated with either R5020 or prolactin, and harvested for luciferase
assay 24 h after hormone treatment. We found that in T47D-YB breast cancer
cells, prolactin alone has minimal to no significant effect on the β-casein luciferase
promoter. However, after R5020 pretreatment, a 6–7-fold induction of the
β-casein luciferase promoter was observed (Fig.7B). Thus R5020 sensitized these
breast cancer cells to the transcriptional effects of prolactin mediated through
Stat5.""" ;
prov:wasQuotedFrom pubmed:9813040 .
sub:_8 rdfs:comment "support@belframework.org" ;
rdfs:label "Selventa" .
sub:assertion prov:hadPrimarySource pubmed:9813040 ;
prov:wasDerivedFrom beldoc: ,
sub:_7 .
}