. . . . . . . . . . . . . . . . . . . . . "TextLocation" . "Results" . "composite(p(HGNC:PRL),a(CHEBIID:59826)) -> tscript(p(PFH:\"STAT5 Family\"))" . "Approximately 2000 hand curated statements drawn from 57 PubMeds." . "Copyright (c) 2011-2012, Selventa. All Rights Reserved." . "BEL Framework Small Corpus Document" . "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" . . "1.6" . "The β-casein promoter, known to be induced by Stat5 when activated by prolactin via\nprolactin receptors and JAK2, was next used to test the function of the phosphorylated\nStat5. T47D-YB cells were pretreated with either R5020 or ethanol vehicle\nfor 48 h. Cells were then washed, transfected with a β-casein promoter-luciferase\nreporter, treated with either R5020 or prolactin, and harvested for luciferase\nassay 24 h after hormone treatment. We found that in T47D-YB breast cancer\ncells, prolactin alone has minimal to no significant effect on the β-casein luciferase\npromoter. However, after R5020 pretreatment, a 6–7-fold induction of the\nβ-casein luciferase promoter was observed (Fig.7B). Thus R5020 sensitized these\nbreast cancer cells to the transcriptional effects of prolactin mediated through\nStat5." . . "support@belframework.org" . "Selventa" . . . . "2014-07-03T14:29:30.808+02:00"^^ . . .