@prefix dc: <http://purl.org/dc/terms/> .
@prefix this: <http://www.tkuhn.ch/bel2nanopub/RA1pnsjW1w-DaAhBS2iMdIKW-i14cc5VcLjA-dD234Eqo> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RA1pnsjW1w-DaAhBS2iMdIKW-i14cc5VcLjA-dD234Eqo#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasPart: <http://purl.obolibrary.org/obo/BFO_0000051> .
@prefix chebi: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix pfh: <http://resource.belframework.org/belframework/1.0/namespace/selventa-named-human-protein-families/> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix atcc: <http://www.lgcstandards-atcc.org/Products/All/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix hasAnnotation: <http://semanticscience.org/resource/SIO_000255> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasPart: chebi:59826, sub:_2 .
  
  sub:_2 geneProductOf: hgnc:9445;
    a Protein: .
  
  sub:_3 hasAgent: sub:_4;
    a go:0042789 .
  
  sub:_4 geneProductOf: pfh:STAT5%20Family;
    a Protein: .
  
  sub:_5 occursIn: mesh:D001943, mesh:D042361, atcc:HTB-133.aspx, species:9606;
    hasAnnotation: sub:_6;
    rdf:object sub:_3;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:_6 dc:subject "TextLocation";
    rdf:value "Results" .
  
  sub:assertion rdfs:label "composite(p(HGNC:PRL),a(CHEBIID:59826)) -> tscript(p(PFH:\"STAT5 Family\"))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 2000 hand curated statements drawn from 57 PubMeds.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved.";
    dce:title "BEL Framework Small Corpus Document";
    dc:license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License";
    pav:authoredBy sub:_8;
    pav:version "1.6" .
  
  sub:_7 prov:value """The β-casein promoter, known to be induced by Stat5 when activated by prolactin via
prolactin receptors and JAK2, was next used to test the function of the phosphorylated
Stat5. T47D-YB cells were pretreated with either R5020 or ethanol vehicle
for 48 h. Cells were then washed, transfected with a β-casein promoter-luciferase
reporter, treated with either R5020 or prolactin, and harvested for luciferase
assay 24 h after hormone treatment. We found that in T47D-YB breast cancer
cells, prolactin alone has minimal to no significant effect on the β-casein luciferase
promoter. However, after R5020 pretreatment, a 6–7-fold induction of the
β-casein luciferase promoter was observed (Fig.7B). Thus R5020 sensitized these
breast cancer cells to the transcriptional effects of prolactin mediated through
Stat5.""";
    prov:wasQuotedFrom pubmed:9813040 .
  
  sub:_8 rdfs:comment "support@belframework.org";
    rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:9813040;
    prov:wasDerivedFrom beldoc:, sub:_7 .
}

sub:pubinfo {
  this: dc:created "2014-07-03T14:29:30.808+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}