. . . . . . . . . . . . . "TextLocation" . "Review" . "g(HGNC:VHL) -- r(HGNC:MET)" . "Approximately 2000 hand curated statements drawn from 57 PubMeds." . "Copyright (c) 2011-2012, Selventa. All Rights Reserved." . "BEL Framework Small Corpus Document" . "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" . . "1.6" . "Importantly, it has been demonstrated that hypoxia promotes tumour cell invasion by\ninducing the expression of the Met receptor [54]. This establishes a mechanism\nwhereby transformed cells can be spurred to exit a hypoxic microenvironment and\ninvade the surrounding tissues, which provide more favourable growth conditions.\nBecause HIF-1a is involved in Met gene expression, the constitutive activation\nof HIF-1a as a consequence of pVHL deregulation provides a mechanism explaining\nthe observation that the expression of HGF and Met receptor is associated with\ngenetic alterations of VHL in primary RCC." . . "support@belframework.org" . "Selventa" . . . . "2014-07-03T14:29:30.338+02:00"^^ . . .