. . . . . . . . . . . "TextLocation" . "Abstract" . "a(CHEBI:UTP) -> a(CHEBI:\"calcium(2+)\")" . "Approximately 2000 hand curated statements drawn from 57 PubMeds." . "Copyright (c) 2011-2012, Selventa. All Rights Reserved." . "BEL Framework Small Corpus Document" . "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" . . "1.6" . "However, IL-1β-induced NF-κB activity is attenuated by increased intracellular calcium\nin response to ionomycin, UTP, or thapsigargin or by overexpression of CaMKKc\nand/or Akt. Ionomycin and CaMKKc overexpression increases Akt phosphorylation\non Thr308 and enzyme activity. Under these conditions or upon overexpression of\nwild type Akt, IL-1β-induced IKKβ activity is diminished. Furthermore, a dominant\nnegative mutant of Akt abolishes IKKβ inhibition by CaMKKc and ionomycin, suggesting\nthat Akt acts as a mediator of CaMKK signaling to inhibit IL-1β-induced\nIKK activity at an upstream target site." . . "support@belframework.org" . "Selventa" . . . . "2014-07-03T14:29:32.779+02:00"^^ . . .