. . . . . . . . . . . . . . . . . . . . . "TextLocation" . "Abstract" . "p(HGNC:TP63) -| (p(HGNC:TP73) -> bp(GO:\"apoptotic process\"))" . "p(HGNC:TP73) -> bp(GO:\"apoptotic process\")" . "Approximately 2000 hand curated statements drawn from 57 PubMeds." . "Copyright (c) 2011-2012, Selventa. All Rights Reserved." . "BEL Framework Small Corpus Document" . "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" . . "1.6" . "Recently, it has been shown that ΔNp63a is also overexpressed in HNSCC cell lines\n(including JHU-012) and in these cells, it acts as a crucial survival factor by\nsuppressing p73-dependent apoptosis.29,32–34 Knockdown of ΔNp63 induces the proapoptotic\nbcl-2-family members Puma and Noxa, and both their induction and cell\ndeath are p53-independent, but require transactivating isoforms of p73. The inhibition\nof p73-dependent transcription by DNp63a involves both direct promoter binding\nand physical sequestration of p73 by protein–protein interaction.29,34–35" . . "support@belframework.org" . "Selventa" . . . . "2014-07-03T14:29:32.679+02:00"^^ . . .