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http://purl.obolibrary.org/obo/RO_0002204
http://www.informatics.jax.org/marker/MGI:107935
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TextLocation
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Results
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p(MGI:Egf) -> bp(GO:"immortalization of host cell")
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p(MGI:Lrig1) -| (p(MGI:Egf) -> bp(GO:"immortalization of host cell"))
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Approximately 2000 hand curated statements drawn from 57 PubMeds.
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Copyright (c) 2011-2012, Selventa. All Rights Reserved.
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BEL Framework Small Corpus Document
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Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License
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In the experiment depicted in Fig. 6A, NIH3T3 cells were transfected with control
vector alone, EGF receptor, or EGF receptor together with LRIG1. Cells were treated
without or with EGF, and colonies were counted after 3.5 weeks of growth. Consistent
with numerous previous reports, we observed that EGF stimulated colony
formation in this assay. This effect was completely blocked when LRIG1 was co-expressed,
but LRIG1 expression was not able to suppress transformation induced by
H-Ras (not shown).
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support@belframework.org
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2014-07-03T14:29:34.155+02:00
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