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All Rights Reserved. http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Small Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/terms/license Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA4dXT7c3nquLnDy7MgKl021_c9Lp_yXyfnwFddvMgNeI#_7 http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/version 1.6 http://www.tkuhn.ch/bel2nanopub/RA4dXT7c3nquLnDy7MgKl021_c9Lp_yXyfnwFddvMgNeI#_6 http://www.w3.org/ns/prov#value Intracellular signaling. Infusion of IGF-I resulted in an approximate fivefold increase in the phosphorylation of ERKs 1 and 2 (Fig. 4), whereas the total ERK levels were unchanged vs. contralateral muscles (data not shown). Coinfusion (IGF+PD) completely blunted the increase in ERK1 phosphorylation and significantly reduced the increase in ERK2 phosphorylation (Fig. 4B). Similar to ERK2, the phosphorylation of S6K1 was increased fivefold in the IGF and 2.8-fold in the IGF+PD muscles (Fig. 5). 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