@prefix this: <
http://www.tkuhn.ch/bel2nanopub/RA8APeGwvxYSn9_Q3NnmKI25HouXJXF3IuSB5Ofu62_Ts
> .
@prefix sub: <
http://www.tkuhn.ch/bel2nanopub/RA8APeGwvxYSn9_Q3NnmKI25HouXJXF3IuSB5Ofu62_Ts#
> .
@prefix beldoc: <
http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel
> .
@prefix rdfs: <
http://www.w3.org/2000/01/rdf-schema#
> .
@prefix rdf: <
http://www.w3.org/1999/02/22-rdf-syntax-ns#
> .
@prefix xsd: <
http://www.w3.org/2001/XMLSchema#
> .
@prefix dct: <
http://purl.org/dc/terms/
> .
@prefix dce: <
http://purl.org/dc/elements/1.1/
> .
@prefix pav: <
http://purl.org/pav/
> .
@prefix np: <
http://www.nanopub.org/nschema#
> .
@prefix belv: <
http://www.selventa.com/vocabulary/
> .
@prefix prov: <
http://www.w3.org/ns/prov#
> .
@prefix go: <
http://amigo.geneontology.org/amigo/term/GO:
> .
@prefix Protein: <
http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080
> .
@prefix hgnc: <
http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=
> .
@prefix geneProductOf: <
http://purl.obolibrary.org/obo/RO_0002204
> .
@prefix hasAgent: <
http://semanticscience.org/resource/SIO_000139
> .
@prefix proteinModification: <
http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000
> .
@prefix psimod: <
http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:
> .
@prefix species: <
http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=
> .
@prefix occursIn: <
http://purl.obolibrary.org/obo/BFO_0000066
> .
@prefix orcid: <
http://orcid.org/
> .
sub:Head
{
this:
np:hasAssertion
sub:assertion
;
np:hasProvenance
sub:provenance
;
np:hasPublicationInfo
sub:pubinfo
;
a
np:Nanopublication
.
}
sub:assertion
{
sub:_1
hasAgent:
sub:_2
;
a
go:0016301
.
sub:_2
geneProductOf:
hgnc:14552
;
a
Protein:
.
sub:_3
belv:variantOf
hgnc:6118
;
a
proteinModification:
,
psimod:00696
.
sub:_4
occursIn:
species:9606
;
rdf:object
sub:_3
;
rdf:predicate
belv:directlyIncreases
;
rdf:subject
sub:_1
;
a
rdf:Statement
.
sub:assertion
rdfs:label
"kin(p(HGNC:IKBKE)) => p(HGNC:IRF3,pmod(P,S,385))" .
}
sub:provenance
{
beldoc:
dce:description
"Approximately 61,000 statements." ;
dce:rights
"Copyright (c) 2011-2012, Selventa. All rights reserved." ;
dce:title
"BEL Framework Large Corpus Document" ;
pav:authoredBy
sub:_7
;
pav:version
"1.4" .
sub:_5
dce:identifier
"REACT_6842.4" ;
dce:title
"REACT_6842.4" ;
dce:type
"Other" .
sub:_6
prov:value
"Human IRF-3 is activated through a two step phosphorylation in the C-terminal domain mediated by TBK1 and/or IKK-i. It requires Ser386 and/or Ser385 (site 1) and a cluster of serine/threonine residues between Ser396 and Ser405 (site 2) [Panne et al 2007]. Phosphorylated residues at site 2 alleviate autoinhibition to allow interaction with CBP (CREB-binding protein) and facilitate phosphorylation at site 1. Phosphorylation at site 1 is required for IRF-3 dimerization." ;
prov:wasQuotedFrom
sub:_5
.
sub:_7
rdfs:label
"Selventa" .
sub:assertion
prov:hadPrimarySource
sub:_5
;
prov:wasDerivedFrom
beldoc:
,
sub:_6
.
}
sub:pubinfo
{
this:
dct:created
"2014-07-03T14:29:42.146+02:00"^^
xsd:dateTime
;
pav:createdBy
orcid:0000-0001-6818-334X
,
orcid:0000-0002-1267-0234
.
}