. . . . . . . . . . . . . . . . "kin(p(HGNC:IKBKE)) => p(HGNC:IRF3,pmod(P,S,385))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "REACT_6842.4" . "REACT_6842.4" . "Other" . "Human IRF-3 is activated through a two step phosphorylation in the C-terminal domain mediated by TBK1 and/or IKK-i. It requires Ser386 and/or Ser385 (site 1) and a cluster of serine/threonine residues between Ser396 and Ser405 (site 2) [Panne et al 2007]. Phosphorylated residues at site 2 alleviate autoinhibition to allow interaction with CBP (CREB-binding protein) and facilitate phosphorylation at site 1. Phosphorylation at site 1 is required for IRF-3 dimerization." . . "Selventa" . . . . "2014-07-03T14:29:42.146+02:00"^^ . . .