@prefix dc: . @prefix this: . @prefix sub: . @prefix beldoc: . @prefix rdfs: . @prefix rdf: . @prefix xsd: . @prefix dce: . @prefix pav: . @prefix np: . @prefix belv: . @prefix prov: . @prefix go: . @prefix Protein: . @prefix pfh: . @prefix geneProductOf: . @prefix hasAgent: . @prefix hgnc: . @prefix hasPart: . @prefix ProteinComplex: . @prefix hasAnnotation: . @prefix species: . @prefix occursIn: . @prefix mesh: . @prefix pubmed: . @prefix orcid: . sub:Head { this: np:hasAssertion sub:assertion; np:hasProvenance sub:provenance; np:hasPublicationInfo sub:pubinfo; a np:Nanopublication . } sub:assertion { sub:_1 hasAgent: sub:_2; a go:0005525 . sub:_2 geneProductOf: pfh:RAS%20Family; a Protein: . sub:_3 hasPart: sub:_4, sub:_5; a ProteinComplex: . sub:_4 geneProductOf: hgnc:9829; a Protein: . sub:_5 geneProductOf: hgnc:1097; a Protein: . sub:_6 occursIn: mesh:D003593, species:9606; hasAnnotation: sub:_7; rdf:object sub:_3; rdf:predicate belv:increases; rdf:subject sub:_1; a rdf:Statement . sub:_7 dc:subject "TextLocation"; rdf:value "Review" . sub:assertion rdfs:label "gtp(p(PFH:\"RAS Family\")) -> complex(p(HGNC:RAF1),p(HGNC:BRAF))" . } sub:provenance { beldoc: dce:description "Approximately 2000 hand curated statements drawn from 57 PubMeds."; dce:rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved."; dce:title "BEL Framework Small Corpus Document"; dc:license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License"; pav:authoredBy sub:_9; pav:version "1.6" . sub:_8 prov:value """The activation of B-Raf by Ras has been less well studied; however, the interacting amino acids in the Ras-Raf interface are identical for B-Raf and C-Raf.129,130 The association of Ras with B-Raf also translocates B-Raf to the cell membrane where it is activated.124 Interestingly, a membrane-free complex of B-Raf and 14-3-3 can be activated in vitro by recombinant Ras. This is in stark contrast to A-Raf and C-Raf, which must undergo a series of phosphorylation reactions on serine and tyrosine residues in the cell membrane and cannot be activated by Ras alone.124,130 Of the Raf isoforms, B-Raf is activated first, and on stimulation by Ras, it heterodimerizes with C-Raf, the significance of which is not known.94"""; prov:wasQuotedFrom pubmed:16170185 . sub:_9 rdfs:comment "support@belframework.org"; rdfs:label "Selventa" . sub:assertion prov:hadPrimarySource pubmed:16170185; prov:wasDerivedFrom beldoc:, sub:_8 . } sub:pubinfo { this: dc:created "2014-07-03T14:29:30.488+02:00"^^xsd:dateTime; pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 . }