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in adipocytes, fasting is associated with the synthesis of Lpl molecules whose N-linked polysaccharide chains retain an unmodified high-mannose structure in the fed state, these chains are modified by mannose trimming, and the addition of glucose, hexosamine and sialic acid units the high mannose form of Lpl has low specific activity and is retained within the adipocyte the modified form is actively secreted insulin levels are an important determinant of Lpl processing
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