[ { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA907boehAyZX1P5p6Jh-84XMvyJ3C6ECnDlyWQd_0NA0", "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ], "http://www.nanopub.org/nschema#hasAssertion" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA907boehAyZX1P5p6Jh-84XMvyJ3C6ECnDlyWQd_0NA0#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA907boehAyZX1P5p6Jh-84XMvyJ3C6ECnDlyWQd_0NA0#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA907boehAyZX1P5p6Jh-84XMvyJ3C6ECnDlyWQd_0NA0#pubinfo" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RA907boehAyZX1P5p6Jh-84XMvyJ3C6ECnDlyWQd_0NA0#Head" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA907boehAyZX1P5p6Jh-84XMvyJ3C6ECnDlyWQd_0NA0#_1", "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697" ], "http://purl.obolibrary.org/obo/RO_0002204" : [ { "@id" : "http://www.informatics.jax.org/marker/MGI:106091" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA907boehAyZX1P5p6Jh-84XMvyJ3C6ECnDlyWQd_0NA0#_2", "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ], "http://purl.obolibrary.org/obo/BFO_0000066" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA907boehAyZX1P5p6Jh-84XMvyJ3C6ECnDlyWQd_0NA0#_1" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ { "@id" : "http://www.selventa.com/vocabulary/increases" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ { "@id" : "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=41564" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA907boehAyZX1P5p6Jh-84XMvyJ3C6ECnDlyWQd_0NA0#assertion", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "a(CHEBI:cholesterol) -> r(MGI:Cyp7a1)" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RA907boehAyZX1P5p6Jh-84XMvyJ3C6ECnDlyWQd_0NA0#assertion" }, { "@graph" : [ { "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel", "http://purl.org/dc/elements/1.1/description" : [ { "@value" : "Approximately 61,000 statements." } ], "http://purl.org/dc/elements/1.1/rights" : [ { "@value" : "Copyright (c) 2011-2012, Selventa. All rights reserved." } ], "http://purl.org/dc/elements/1.1/title" : [ { "@value" : "BEL Framework Large Corpus Document" } ], "http://purl.org/pav/authoredBy" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA907boehAyZX1P5p6Jh-84XMvyJ3C6ECnDlyWQd_0NA0#_5" } ], "http://purl.org/pav/version" : [ { "@value" : "1.4" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA907boehAyZX1P5p6Jh-84XMvyJ3C6ECnDlyWQd_0NA0#_3", "http://purl.org/dc/elements/1.1/identifier" : [ { "@value" : "Biochemistry of Lipids, Lipoproteins and Membranes 2002 - Chapter 16" } ], "http://purl.org/dc/elements/1.1/title" : [ { "@value" : "Biochemistry of Lipids, Lipoproteins and Membranes 2002 - Chapter 16" } ], "http://purl.org/dc/elements/1.1/type" : [ { "@value" : "Book" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA907boehAyZX1P5p6Jh-84XMvyJ3C6ECnDlyWQd_0NA0#_4", "http://www.w3.org/ns/prov#value" : [ { "@value" : "Page 442 Feeding rats with a cholesterol-enriched diet induces bile acid synthesis. This increase is attributable to the rise in cyp7a activity, which catalyzes the rate-limiting step of the classical pathway. Interrupting the return of bile acids to the liver, by diverting bile or by feeding a bile acid-binding resin, also stimulates the synthesis of bile acids. In contrast, reintroduction of bile acids into bile-diverted rats reverses the stimulatory effect, indicating that bile acid synthesis is subject to end-product inhibition. It was later discovered that cyp7a enzyme activity is closely correlated with cyp7a mRNA abundance, indicating that cyp7a gene transcription is the major determinant of cyp7a activity." } ], "http://www.w3.org/ns/prov#wasQuotedFrom" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA907boehAyZX1P5p6Jh-84XMvyJ3C6ECnDlyWQd_0NA0#_3" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA907boehAyZX1P5p6Jh-84XMvyJ3C6ECnDlyWQd_0NA0#_5", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "Selventa" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA907boehAyZX1P5p6Jh-84XMvyJ3C6ECnDlyWQd_0NA0#assertion", "http://www.w3.org/ns/prov#hadPrimarySource" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA907boehAyZX1P5p6Jh-84XMvyJ3C6ECnDlyWQd_0NA0#_3" } ], "http://www.w3.org/ns/prov#wasDerivedFrom" : [ { "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel" }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA907boehAyZX1P5p6Jh-84XMvyJ3C6ECnDlyWQd_0NA0#_4" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RA907boehAyZX1P5p6Jh-84XMvyJ3C6ECnDlyWQd_0NA0#provenance" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA907boehAyZX1P5p6Jh-84XMvyJ3C6ECnDlyWQd_0NA0", "http://purl.org/dc/terms/created" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2014-07-03T14:29:44.572+02:00" } ], "http://purl.org/pav/createdBy" : [ { "@id" : "http://orcid.org/0000-0001-6818-334X" }, { "@id" : "http://orcid.org/0000-0002-1267-0234" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RA907boehAyZX1P5p6Jh-84XMvyJ3C6ECnDlyWQd_0NA0#pubinfo" } ]