. . . . . . . . . . . "a(CHEBI:cholesterol) -> r(MGI:Cyp7a1)" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "Biochemistry of Lipids, Lipoproteins and Membranes 2002 - Chapter 16" . "Biochemistry of Lipids, Lipoproteins and Membranes 2002 - Chapter 16" . "Book" . "Page 442 Feeding rats with a cholesterol-enriched diet induces bile acid synthesis. This increase is attributable to the rise in cyp7a activity, which catalyzes the rate-limiting step of the classical pathway. Interrupting the return of bile acids to the liver, by diverting bile or by feeding a bile acid-binding resin, also stimulates the synthesis of bile acids. In contrast, reintroduction of bile acids into bile-diverted rats reverses the stimulatory effect, indicating that bile acid synthesis is subject to end-product inhibition. It was later discovered that cyp7a enzyme activity is closely correlated with cyp7a mRNA abundance, indicating that cyp7a gene transcription is the major determinant of cyp7a activity." . . "Selventa" . . . . "2014-07-03T14:29:44.572+02:00"^^ . . .