http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#Head http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#assertion http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#provenance http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#pubinfo http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#assertion http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6204 http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#_2 http://semanticscience.org/resource/SIO_000255 http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#_3 http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://purl.bioontology.org/ontology/MSH/D002294 http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#_1 http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#_3 http://purl.org/dc/terms/subject TextLocation http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#value Results http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#assertion http://www.w3.org/2000/01/rdf-schema#label p(HGNC:JUN) -> path(MESHD:"Carcinoma, Squamous Cell") http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#provenance http://resource.belframework.org/belframework/20131211/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 2000 hand curated statements drawn from 57 PubMeds. http://resource.belframework.org/belframework/20131211/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All Rights Reserved. http://resource.belframework.org/belframework/20131211/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Small Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/small_corpus.bel http://purl.org/dc/terms/license Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License http://resource.belframework.org/belframework/20131211/knowledge/small_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#_5 http://resource.belframework.org/belframework/20131211/knowledge/small_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#_4 http://www.w3.org/ns/prov#value We next asked whether components of the JNK cascade could directly promote human epidermal neoplasia. We expressed either active MKK7 or c-Jun in primary keratinocytes and examined their capacity to promote tumorigenesis in combination with Ras in the absence of IκBα. First, we confirmed induction of AP1-dependent gene reporter activity by MKK7 in vitro (Supplementary Fig. S4). Surface skin grafts were then regenerated with primary keratinocytes expressing MKK7 and Ras; these developed into clinical tumors resembling SCC (Fig. 3A). Dermal invasion, one of the hallmarks of spontaneous human SCC, is apparent in tumors induced by MKK7 and Ras as revealed by both histologic appearance and BMZ disruption (Fig. 3B–C). MKK7 and Ras-induced neoplasia depends on intact AP1 function as concurrent expression of DNc-Jun prevents tumorigenesis (Fig. 3A–C). http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17440097 http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#_5 http://www.w3.org/2000/01/rdf-schema#comment support@belframework.org http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17440097 http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/small_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#_4 http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls#pubinfo http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls http://purl.org/dc/terms/created 2014-07-03T14:31:17.287+02:00 http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA9_iO6W6jT2-17KnDw4dz9yCX2ATnIsIipTc2ubBuHls http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234