. . . . . . . . . . . . . "TextLocation" . "Abstract" . "p(HGNC:SELE) -> bp(GOBP:\"heterotypic cell-cell adhesion\")" . "Approximately 2000 hand curated statements drawn from 57 PubMeds." . "Copyright (c) 2011-2012, Selventa. All Rights Reserved." . "BEL Framework Small Corpus Document" . "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" . . "20131211" . "Adhesion of HT-29 cells on a monolayer of HUVEC pretreated with TNFα was dependent\non E-selectin expression but was independent of SAPK2/p38 activity of both HUVEC\nand tumor cells. The adhesion of HT-29 cells to E-selectin-expressing HUVEC led\nto the activation of SAPK2/p38 in the tumor cells as reflected by the increased\nphosphorylation of the actin-polymerizing factor HSP27 by mitogen-activated protein\nkinase 2/3, a direct target of SAPK2/p38. Moreover, a recombinant E-selectin/Fc\nchimera quickly increased the activation of SAPK2/p38 in HT-29 cells. Blocking\nthe increased activity of SAPK2/p38 of HT-29 cells by SB203580 or by expressing\na dominant negative form of SAPK2/p38 inhibited their transendothelial migration." . . "support@belframework.org" . "Selventa" . . . . "2014-07-03T14:31:17.681+02:00"^^ . . .