. . . . . . . . . . . . . . . . . . "TextLocation" . "Review" . "p(HGNC:RAF1,pmod(P,Y,341)) => kin(p(HGNC:RAF1))" . "Approximately 2000 hand curated statements drawn from 57 PubMeds." . "Copyright (c) 2011-2012, Selventa. All Rights Reserved." . "BEL Framework Small Corpus Document" . "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" . . "1.6" . "Raf is also phosphorylated at other serine and threonine residues, the most important\nof which are S338 and tyrosine (Y) 341, which are situated adjacent to the\nC-Raf kinase domain.140 Phosphorylation of these residues relieves the inhibitory\neffects of the regulatory domain on the kinase domain.141 S338, which is the\nevolutionarily conserved PAK phosphorylation site that resides on the amino-terminal\nside of the kinase domain, is critical for Raf activation.134-136,140,142\n This site is also phosphorylated in response to stimulation by growth factors,\nintegrins, Ras, PAK1, and PAK3.78,136,143" . . "support@belframework.org" . "Selventa" . . . . "2014-07-03T14:29:30.543+02:00"^^ . . .