. . . . . . . . . . . . . "TextLocation" . "Review" . "a(CHEBI:amiodarone) -> bp(GO:\"regulation of oxidative phosphorylation uncoupler activity\")" . "Approximately 2000 hand curated statements drawn from 57 PubMeds." . "Copyright (c) 2011-2012, Selventa. All Rights Reserved." . "BEL Framework Small Corpus Document" . "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" . . "1.6" . "Cationic amphiphilic drugs such as amiodarone, perhexiline, diethylaminoethoxyhexestrol\n(DEAEH) and tamoxifen can be first protonated in the intermembrane space\nof mitochondria, and then electrophoretically transported into the mitochondrial\nmatrix thanks to the Δψm [3,4,40,42], as discussed in greater detail below. This\ntransfer across the inner mitochondrial membrane dissipates Δψm (Figure 1) and\nincreases the basal (state 4) mitochondrial respiration. This phenomenon, which\nis called 'OXPHOS uncoupling', can also be observed in the case of some mitochondrial\npoisons such as the protonophores 2,4-dinitrophenol (DNP) and carbonylcyanide\np-trifluoromethoxyphenylhydrazone (FCCP)." . . "support@belframework.org" . "Selventa" . . . . "2014-07-03T14:29:31.097+02:00"^^ . . .