@prefix dc: . @prefix this: . @prefix sub: . @prefix beldoc: . @prefix rdfs: . @prefix rdf: . @prefix xsd: . @prefix dce: . @prefix pav: . @prefix np: . @prefix belv: . @prefix prov: . @prefix chebi: . @prefix go: . @prefix hasAnnotation: . @prefix species: . @prefix occursIn: . @prefix mesh: . @prefix pubmed: . @prefix orcid: . sub:Head { this: np:hasAssertion sub:assertion; np:hasProvenance sub:provenance; np:hasPublicationInfo sub:pubinfo; a np:Nanopublication . } sub:assertion { sub:_1 occursIn: mesh:D007728, mesh:D008099, mesh:D008930, species:9606; hasAnnotation: sub:_2; rdf:object go:2000275; rdf:predicate belv:increases; rdf:subject chebi:2663; a rdf:Statement . sub:_2 dc:subject "TextLocation"; rdf:value "Review" . sub:assertion rdfs:label "a(CHEBI:amiodarone) -> bp(GO:\"regulation of oxidative phosphorylation uncoupler activity\")" . } sub:provenance { beldoc: dce:description "Approximately 2000 hand curated statements drawn from 57 PubMeds."; dce:rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved."; dce:title "BEL Framework Small Corpus Document"; dc:license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License"; pav:authoredBy sub:_4; pav:version "1.6" . sub:_3 prov:value """Cationic amphiphilic drugs such as amiodarone, perhexiline, diethylaminoethoxyhexestrol (DEAEH) and tamoxifen can be first protonated in the intermembrane space of mitochondria, and then electrophoretically transported into the mitochondrial matrix thanks to the Δψm [3,4,40,42], as discussed in greater detail below. This transfer across the inner mitochondrial membrane dissipates Δψm (Figure 1) and increases the basal (state 4) mitochondrial respiration. This phenomenon, which is called 'OXPHOS uncoupling', can also be observed in the case of some mitochondrial poisons such as the protonophores 2,4-dinitrophenol (DNP) and carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP)."""; prov:wasQuotedFrom pubmed:18705745 . sub:_4 rdfs:comment "support@belframework.org"; rdfs:label "Selventa" . sub:assertion prov:hadPrimarySource pubmed:18705745; prov:wasDerivedFrom beldoc:, sub:_3 . } sub:pubinfo { this: dc:created "2014-07-03T14:29:31.097+02:00"^^xsd:dateTime; pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 . }