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created: 2018-12-15T09:32:57.475+01:00
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was generated by: activity

f1125
organism name: Homo sapiens
source: ENSG00000128652
target: ENST00000249440
type: Interaction

Activation of anterior HOX genes in hindbrain development during early embryogenesis

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was generated by: activity

a084c
organism name: Homo sapiens
source: R-HSA-5675767
source: R-HSA-5675788
target: R-HSA-5675769
type: Interaction

TNFs bind their physiological receptors

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was generated by: activity

f992b
organism name: Homo sapiens
source: CHEBI:15422
source: CHEBI:18348
target: CHEBI:16618
target: CHEBI:16761
type: Interaction

Signaling by FGFR3

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was generated by: activity

a396f
organism name: Homo sapiens
source: CHEBI:15379
source: CHEBI:16474
target: CHEBI:15378
target: CHEBI:18009
target: CHEBI:18421
type: Interaction

RHO GTPases Activate NADPH Oxidases

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was generated by: activity

caec8
organism name: Homo sapiens
source: ENSG00000182934
target: P08240
type: Interaction

XBP1(S) activates chaperone genes

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was generated by: activity

be592
organism name: Homo sapiens
source: P17936
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target: R-HSA-6800024
type: Interaction

TP53 Regulates Transcription of Cell Death Genes

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was generated by: activity

f4e6c
organism name: Homo sapiens
source: R-HSA-5334772
target: R-HSA-5334770
type: Interaction

Uptake and function of diphtheria toxin

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was generated by: activity

cbadd
organism name: Homo sapiens
source: R-HSA-5607694
target: R-HSA-113595
target: R-HSA-5607699
type: Interaction

C-type lectin receptors (CLRs)

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was generated by: activity

f8ed6
organism name: Homo sapiens
source: ENSG00000106366
target: P05121
type: Interaction

BMAL1:CLOCK,NPAS2 activates circadian gene expression

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ca609
organism name: Homo sapiens
source: CHEBI:15422
source: R-HSA-4793790
target: CHEBI:16761
target: R-HSA-5082354
type: Interaction

Cellular response to heat stress

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was generated by: activity

ad84b
organism name: Homo sapiens
source: R-HSA-1632839
source: R-HSA-5676032
target: R-HSA-5678311
type: Interaction

Macroautophagy

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was generated by: activity

a4c32
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source: CHEBI:15377
source: CHEBI:91284
target: CHEBI:4208
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type: Interaction

Lysosomal oligosaccharide catabolism

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was generated by: activity

dfc02
organism name: Homo sapiens
source: R-HSA-2993783
source: Q13426
target: R-HSA-4568891
target: P63279
type: Interaction

SUMOylation of DNA damage response and repair proteins

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was generated by: activity

e3b97
organism name: Bos taurus
source: ENSBTAG00000019472
target: ENSBTAG00000016206
type: Interaction

SIDS Susceptibility Pathways

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was generated by: activity

f9542
organism name: Homo sapiens
source: CHEBI:17806
source: CHEBI:64729
target: CHEBI:77008
type: Interaction

Selenoamino acid metabolism

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rights: http://creativecommons.org/publicdomain/zero/1.0/
was generated by: activity

c2957
organism name: Homo sapiens
source: Q06609
target: P43351
type: Interaction

DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM

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was generated by: activity

a3620
organism name: Homo sapiens
source: CHEBI:15422
source: CHEBI:15713
source: CHEBI:15996
source: CHEBI:17677
source: R-HSA-6814534
target: R-HSA-6814537
type: Interaction

RNA polymerase II transcribes snRNA genes

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was generated by: activity

adf7b
organism name: Homo sapiens
source: http://identifiers.org/ncbigene/3791
target: http://identifiers.org/ncbigene/8821
type: Interaction

VEGFA-VEGFR2 Signaling Pathway

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was generated by: activity

c1087
organism name: Homo sapiens
source: http://identifiers.org/ncbigene/5879
target: http://identifiers.org/ncbigene/5062
type: Interaction

RA4LMCANO6sVavUgeH1hWW8VPDTXmhsh1pJkdq7Wpvag4
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type: Nanopublication
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was generated by: activity

e434d
organism name: Homo sapiens
source: CHEBI:15422
source: R-HSA-2029952
target: CHEBI:16761
target: R-HSA-2029948
type: Interaction

Signaling by FGFR2

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was generated by: activity

e4812
organism name: Homo sapiens
source: R-HSA-507919
target: R-HSA-508012
type: Interaction

Signaling by Leptin

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created: 2018-12-15T09:32:57.475+01:00
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was generated by: activity

c030a
organism name: Homo sapiens
source: CHEBI:15378
source: CHEBI:16474
source: R-HSA-975639
target: CHEBI:18009
target: R-HSA-975626
type: Interaction

Retinoid metabolism and transport

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was generated by: activity

idd899642
organism name: Homo sapiens
source: Q07812
target: O14727
type: Interaction

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created: 2018-12-15T09:32:57.475+01:00
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was generated by: activity

d396f
organism name: Homo sapiens
source: R-HSA-5621783
target: R-HSA-5621787
type: Interaction

Hedgehog 'off' state

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was generated by: activity

c8cd0
organism name: Homo sapiens
source: CHEBI:15414
target: CHEBI:16680
target: M11167
type: Interaction

rRNA modification in the nucleus and cytosol

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was generated by: activity

c89e2
organism name: Homo sapiens
source: R-HSA-3785763
source: R-HSA-5682037
target: R-HSA-3785779
type: Interaction

DNA Double Strand Break Response

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was generated by: activity

d427b
organism name: Homo sapiens
source: ENSG00000137752
source: R-HSA-6798076
target: R-HSA-6798078
type: Interaction

RA46cCM586dBb9zLch-UaMF7FKqHsTrcya-JAiIZU8QJ4
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created: 2018-12-15T09:32:57.475+01:00
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was generated by: activity

c8583
organism name: Homo sapiens
source: CHEBI:15377
source: R-HSA-3222079
target: R-HSA-6805030
target: R-HSA-68524
target: Q93009
target: Q9UER7
type: Interaction

Regulation of TP53 Expression and Degradation

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was generated by: activity

ecd11
organism name: Homo sapiens
source: CHEBI:16556
target: CHEBI:16556
type: Interaction

Sialic acid metabolism

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was generated by: activity

d3819
organism name: Homo sapiens
source: CHEBI:16556
source: CHEBI:61248
target: CHEBI:17361
target: CHEBI:75129
type: Interaction

RAzQehjtUmLFfNfe9K9mYPflYm33k2o0f4eK6JsrC7oAg
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was generated by: activity

c2d6f
organism name: Homo sapiens
source: CHEBI:15377
source: CHEBI:17552
source: R-HSA-983418
target: CHEBI:15996
target: R-HSA-203989
target: R-HSA-203991
target: R-HSA-983412
target: O94979
target: P55735
target: Q15436
type: Interaction

Class I MHC mediated antigen processing & presentation

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was generated by: activity

c2ec9
organism name: Homo sapiens
source: CHEBI:15414
source: R-HSA-3788743
target: CHEBI:16680
target: R-HSA-3788746
type: Interaction

Senescence-Associated Secretory Phenotype (SASP)

RA4L6JHfljZYUre-Pq0cRo cnVVDN7ogyjFV40nvY Bbk
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was generated by: activity

ce3c1
organism name: Homo sapiens
source: CHEBI:15422
source: R-HSA-5623637
target: CHEBI:16761
target: R-HSA-377179
target: R-HSA-5623659
target: R-HSA-5624294
type: Interaction

RHO GTPases activate PKNs

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was generated by: activity

R-HSA-5607687
type: Complex
is part of: WP1927
organism name: Homo sapiens

c6c13
organism name: Homo sapiens
source: R-HSA-5607687
source: R-HSA-5607698
target: R-HSA-5607693
type: Interaction

NIK-->noncanonical NF-kB signaling

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b217d
organism name: Homo sapiens
source: CHEBI:15422
source: R-HSA-8847640
target: CHEBI:16761
target: R-HSA-2193131
target: R-HSA-5694313
target: O15498
target: O95249
target: Q13190
target: Q9NYM9
type: Interaction

Intra-Golgi and retrograde Golgi-to-ER traffic

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was generated by: activity

dc24f
organism name: Homo sapiens
source: CHEBI:15422
source: R-HSA-2023433
target: CHEBI:16761
target: R-HSA-2023432
type: Interaction

Signaling by FGFR1

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was generated by: activity

ebe05
organism name: Homo sapiens
source: R-HSA-179864
source: R-HSA-5654198
target: R-HSA-5654199
type: Interaction

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was generated by: activity

b8884
organism name: Homo sapiens
source: CHEBI:15377
source: CHEBI:16335
target: CHEBI:16134
target: CHEBI:17596
type: Interaction

Surfactant metabolism

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was generated by: activity

de394
organism name: Homo sapiens
source: CHEBI:15377
source: R-HSA-2025924
source: R-HSA-2025947
target: CHEBI:18367
target: R-HSA-2685705
type: Interaction

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was generated by: activity

c9ba5
organism name: Homo sapiens
source: O15527
target: R-HSA-110186
type: Interaction

Base-Excision Repair, AP Site Formation

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was generated by: activity

d9652
organism name: Homo sapiens
source: ENSG00000138685
target: P09038
type: Interaction

POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation

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was generated by: activity

c2cf9
organism name: Homo sapiens
source: P05067
source: Q92673
target: R-HSA-8871479
type: Interaction

Amyloid fiber formation

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was generated by: activity

d3245
organism name: Homo sapiens
source: CHEBI:15422
source: R-HSA-2033349
target: CHEBI:16761
target: R-HSA-2033348
type: Interaction

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created: 2018-12-15T09:32:57.475+01:00
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was generated by: activity

f9744
organism name: Homo sapiens
source: R-HSA-165678
target: CHEBI:18367
target: R-HSA-5693447
type: Interaction

TP53 Regulates Metabolic Genes

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was generated by: activity

aaf04
organism name: Homo sapiens
source: CHEBI:15414
source: R-HSA-3788741
target: CHEBI:16680
target: R-HSA-3788744
type: Interaction

RAw45NMcOvf71oZGocPkyeHg-EVL7j31OHVGzykqKp34A
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cc89f
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type: Interaction

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c968c
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a736d
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Hedgehog 'on' state

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f6609
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Serotonin Receptor 2 and ELK-SRF/GATA4 signaling

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e531e
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Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism

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c6a82
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Mismatch Repair

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d8a73
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Vitamin D (calciferol) metabolism

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d6a56
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f6731
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e5661
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Metallothioneins bind metals

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fd5aa
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f39ad
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RHO GTPases Activate WASPs and WAVEs

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a067c
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MAPK6/MAPK4 signaling

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d559a
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TCF dependent signaling in response to WNT

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c3bb8
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Nonhomologous End-Joining (NHEJ)

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cffd0
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cd8a1
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type: Interaction

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e0d6c
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Amine-derived hormones

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c6f9c
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c51d7
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f251b
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b9a1b
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EPH-Ephrin signaling

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b7ff2
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HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)

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a28c0
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DNA Damage/Telomere Stress Induced Senescence

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aebe6
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cf1fe
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RHO GTPases activate CIT

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b75fa
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Branched-chain amino acid catabolism

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ffb29
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type: Interaction

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f623b
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d4427
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Uptake and function of anthrax toxins

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d148b
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Resolution of Abasic Sites (AP sites)

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e4da9
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ad00d
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ROS, RNS production in phagocytes

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ida1a715a
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ad510
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e2e6e
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type: Interaction

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a3fba
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type: Interaction

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cf2a3
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source: R-HSA-6798076
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Regulation of TP53 Activity through Association with Co-factors

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id4cde5054
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f68bd
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R-HSA-5683605
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a3197
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a8824
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bd5b8
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a6b60
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type: Interaction

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e4dfa
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da8ee
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trans-Golgi Network Vesicle Budding

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b7909
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dd49f
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Hedgehog ligand biogenesis

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ce0e1
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TNF signaling

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ad75d
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d5e2f
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a30cb
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e9fba
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Fanconi Anemia Pathway

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dca35
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bffbd
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fe0d0
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a5970
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TRAIL signaling

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P13639
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R-HSA-6803802
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cea07
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TP53 Regulates Transcription of Cell Cycle Genes

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d121f
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Major pathway of rRNA processing in the nucleolus and cytosol

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b7e0b
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SUMOylation of chromatin organization proteins

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d8c06
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d52d4
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Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3

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f9a49
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d0c4f
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c4e87
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adbb0
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Regulated Necrosis

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a3a38
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f8e4b
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TNFR2 non-canonical NF-kB pathway

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b2134
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f4c3f
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Mitochondrial biogenesis

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b54b9
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ef73c
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ccb18
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Beta-catenin independent WNT signaling

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beac3
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Interleukin-20 family signaling

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http://identifiers.org/ncbigene/7295
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organism name: Mus musculus
organism name: Rattus norvegicus

ead68
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bd5cc
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Signaling by PTK6

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c6b45
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Vitamin E

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e5325
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Class A/1 (Rhodopsin-like receptors)

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cd09e
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Nucleobase catabolism

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c040d
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Phase II - Conjugation of compounds

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b1c3c
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Biosynthesis of DHA-derived SPMs

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adb82
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Chromatin organization

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d75ce
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ESR-mediated signaling

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a4466
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type: Interaction

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b941b
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Biosynthesis of DPA-derived SPMs

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cd439
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G alpha (12/13) signalling events

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f688a
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Activation of NMDA receptors and postsynaptic events

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a7ea1
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E3 ubiquitin ligases ubiquitinate target proteins

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e9fe7
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Transcriptional regulation by RUNX1

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f08d6
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was generated by: activity

ddb13
organism name: Homo sapiens
source: R-HSA-8936213
source: P01559
target: R-HSA-8936363
type: Interaction

Intestinal infectious diseases

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fdbe8
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Interleukin-12 family signaling

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fc12d
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Transcriptional Regulation by E2F6

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fae02
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source: P40222
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type: Interaction

Other interleukin signaling

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b2689
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type: Interaction

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c5d37
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Deubiquitination

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f4312
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fd9cd
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type: Interaction

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was generated by: activity

a1727
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source: CHEBI:29101
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Intestinal absorption

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b9ab6
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target: R-HSA-8950372
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type: Interaction

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was generated by: activity

cbaef
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source: R-HSA-177505
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target: R-HSA-6784733
type: Interaction

Plasma lipoprotein assembly, remodeling, and clearance

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was generated by: activity

de84e
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source: CHEBI:15946
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Pentose phosphate pathway

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was generated by: activity

c195d
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Regulation of RUNX1 Expression and Activity

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bfbb2
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source: CHEBI:52288
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target: R-HSA-417887
type: Interaction

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was generated by: activity

b385e
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Transcriptional regulation by RUNX2

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cde77
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source: CHEBI:15996
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Integrin alphaIIb beta3 signaling

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d1ca8
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source: CHEBI:15414
source: R-HSA-8936615
target: CHEBI:16680
target: R-HSA-8936620
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RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

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e473d
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target: Q14527
type: Interaction

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was generated by: activity

idf93de1f6
organism name: Homo sapiens
source: Q01094
target: P38398
type: Interaction

DNA IR-damage and cellular response via ATR

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was generated by: activity

b2cb9
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source: ENSG00000118523
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Transcriptional regulation by RUNX3

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c745f
organism name: Homo sapiens
source: CHEBI:15422
source: R-HSA-8983118
target: CHEBI:16761
target: R-HSA-8983137
type: Interaction

Interleukin-15 signaling

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was generated by: activity

deb86
organism name: Homo sapiens
source: CHEBI:15978
source: CHEBI:16238
target: CHEBI:16108
target: CHEBI:17877
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Triglyceride metabolism

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was generated by: activity

ff00f
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source: CHEBI:15377
source: CHEBI:16192
target: CHEBI:16235
target: CHEBI:19569
type: Interaction

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was generated by: activity

ea0a2
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source: P23458
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Interleukin-9 signaling

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was generated by: activity

d0ce1
organism name: Homo sapiens
source: R-HSA-168946
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target: R-HSA-5432872
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Regulation of TLR by endogenous ligand

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was generated by: activity

e61ef
organism name: Homo sapiens
source: R-HSA-6794303
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target: R-HSA-6794314
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Neurexins and neuroligins

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e01d8
organism name: Homo sapiens
source: R-HSA-2173282
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Collagen chain trimerization

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eb812
organism name: Homo sapiens
source: R-HSA-392161
target: CHEBI:18367
target: R-HSA-392164
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G alpha (i) signalling events

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b6dc3
organism name: Homo sapiens
source: R-HSA-8984010
target: R-HSA-8985392
target: P40763
target: P42224
type: Interaction

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b87e1
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source: CHEBI:15414
source: ENST00000387347
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rRNA modification in the mitochondrion

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b6776
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source: R-HSA-5626175
source: Q8TES7
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target: R-HSA-5626176
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Cilium Assembly

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a9392
organism name: Homo sapiens
source: ENSG00000055332
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Ebola Virus Pathway on Host

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b08ee
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source: CHEBI:15343
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target: CHEBI:15366
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Phase I - Functionalization of compounds

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b89fa
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target: CHEBI:15378
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OAS antiviral response

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f0c4a
organism name: Homo sapiens
source: CHEBI:138641
target: CHEBI:138643
type: Interaction

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b5925
organism name: Homo sapiens
source: CHEBI:15422
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target: CHEBI:16761
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type: Interaction

RAB GEFs exchange GTP for GDP on RABs

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was generated by: activity

c710a
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source: CHEBI:15377
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target: CHEBI:15346
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Fatty acyl-CoA biosynthesis

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e10a4
organism name: Homo sapiens
source: R-ALL-9023979
target: R-ALL-9023981
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Biosynthesis of EPA-derived SPMs

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c0664
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source: CHEBI:17931
source: CHEBI:17980
target: CHEBI:17985
target: CHEBI:35424
type: Interaction

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was generated by: activity

d4a5e
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source: CHEBI:15531
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type: Interaction

Mitochondrial Fatty Acid Beta-Oxidation

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e06f6
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source: R-HSA-8950383
target: R-HSA-8950589
target: P27824
type: Interaction

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c03a7
organism name: Homo sapiens
source: CHEBI:15379
source: CHEBI:15843
target: CHEBI:27647
type: Interaction

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bbcd8
organism name: Homo sapiens
source: P35225
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Interleukin-4 and Interleukin-13 signaling

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e764c
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source: CHEBI:29108
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source: P0DP23
target: R-HSA-442735
type: Interaction

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de2c8
organism name: Homo sapiens
source: CHEBI:15377
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Digestion

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ef8a3
organism name: Homo sapiens
source: R-HSA-373259
source: P13501
target: R-HSA-373299
type: Interaction

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was generated by: activity

dab1a
organism name: Homo sapiens
source: ENSG00000134460
target: P01589
type: Interaction

RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

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bd178
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DNA Replication Pre-Initiation

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cff8e
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d50d2
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d7305
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Import of palmitoyl-CoA into the mitochondrial matrix

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dc358
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RET signaling

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c6cdd
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Nicotinate metabolism

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a789f
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Biosynthesis of electrophilic ?-3 PUFA oxo-derivatives

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fe496
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d0c81
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dac37
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Galactose catabolism

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c0d5a
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Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

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c9026
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PTEN Regulation

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af11d
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fc0d2
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Signaling by MET

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Nucleotide salvage

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c5a68
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fa57c
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c48a0
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Interleukin-10 signaling

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af235
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f7e5b
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SUMOylation of transcription cofactors

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fc13d
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af087
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d8522
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Neddylation

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a04d0
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Antimicrobial peptides

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aa889
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p75 NTR receptor-mediated signalling

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Peroxisomal protein import

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fad60
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cb615
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b4340
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fa0b5
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df8d0
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Cargo recognition for clathrin-mediated endocytosis

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d0a97
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e9292
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Serine biosynthesis

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type: Interaction

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e2265
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COPII-mediated vesicle transport

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efc39
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fdd53
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e8b5c
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a297d
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type: Interaction

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ce91c
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Glycogen metabolism

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d587f
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f6eb2
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Listeria monocytogenes entry into host cells

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ca401
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Transcription from mitochondrial promoters

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e23ba
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c42ce
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Lipid particle organization

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Interconversion of nucleotide di- and triphosphates

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Activation of kainate receptors upon glutamate binding

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Transcriptional Regulation by MECP2

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TBC/RABGAPs

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RNA Polymerase I Transcription

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Ketone body metabolism

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Class B/2 (Secretin family receptors)

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Glucose metabolism

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COPI-mediated anterograde transport

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dc73c
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type: Interaction

Keratinization

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b28ac
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Protein ubiquitination

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f183a
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Ion channel transport

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c653a
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e5fdc
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Signaling by Erythropoietin

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Synaptic adhesion-like molecules

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c8eea
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Nucleobase biosynthesis

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f691e
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c5389
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a8bf1
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e26de
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fa19d
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f3d76
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e0e2f
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aa53b
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Glutamate binding, activation of AMPA receptors and synaptic plasticity

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e2d5a
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a8f38
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c5540
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Signaling by Retinoic Acid

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a493a
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a1e79
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b1ce9
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a5915
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eec2d
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Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors

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f0ae8
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e3cc1
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d1653
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ac7db
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fbcc3
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c3207
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bdd36
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fd217
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Clathrin-mediated endocytosis

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fcc49
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f9fd6
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RAB geranylgeranylation

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c671a
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Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation

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db285
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cdd2e
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Signaling by NTRK3 (TRKC)

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af93a
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f9eaa
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af8b7
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Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models

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G alpha (q) signalling events

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Regulation of RUNX2 expression and activity

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Butyrophilin (BTN) family interactions

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G alpha (s) signalling events

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RNA Polymerase III Transcription

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PI3K Cascade

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Mitochondrial calcium ion transport

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